N-nitrosobis(2-oxopropyl)amineによるハムスター膵管癌発生に対するtranexamic acid及びphenyl N-tert-butylnitroneの影響

Abstract

Effects of tranexamic acid (TA), a plasminogen activator inhibitor, and phenyl N-tert-butylnitrone (PBN), an inducible nitric oxide synthase (iNOS) inhibitor, on pancreatic duct carcinogenesis were investigated using a rapid production model for pancreatic duct carcinoma in hamsters, and the following results were obtained. 1. No toxic signs including growth retardation or loss of pancreatic weights were obser- ved in hamsters treated with BOP followed by TA or PBN. 2. As pancreatic duct lesions, duct epithelial hyperplasia, atypical hyperplasia and adenocarcinoma were histologically observed in all of the experimental groups. 3. The diet containing 0.1% TA reduced both the incidence and number of adenocar- cmomas. 4. The drinking water containing 0.05% PBN did not affect any of the pancreatic lesions with statistically significant differences. 5. TA or PBN did not affect the PCNA labeling indices of pancreatic ductal lesions. 6. TA reduced inflammatory reactions in the surrounding tissue of pancreatic ductal lesions, but PBN did not have an effect. These results indicate that TA possesses inhibitory effects on the development of pancreatic duct carcinomas, while PBN did not clearly show such effects.