http://hdl.handle.net/10564/1640 1994年度博士論文 2026-04-09T19:26:02Z http://hdl.handle.net/10564/1623 タイトル: 非定型抗酸菌(Mycobacterium avium-intracellulare complex)症患者における末梢血単核球サイトカイン産生能に関する研究 著者: 友田, 恒一 抄録: Cytokine productions of peripheral blood lymphocytes (PBLs) and monocytes (PBMs) from patients with Mycobacterium avium-intracellulare complex (MAC) infection were assessed. PPD-S prepared from M. tuberculosis, PPD-B from M. intracellulare, and PPD-Y from M. kansasii, were used as stimulants. PBLs from patients with active MAC did not produce IFN-γ to a significant extent upon stimulation with any of three PPDs, while PBLs from patients with inactive MAC showed higher responses to each PPD with the maximal response to PPD-B antigens. On the other hand, PBLs from healthy controls produced IFN-γ with the maximal response to PPD-S. Spontaneous release of both TNFα and IL-6 by PBMs from patients at the active stage was higher than those by the cells of the inactive stage patients or healthy controls. When PBMs were stimulated with MAC-derived PPD (PPD-B), increased TNFα production was obtained for PBMs of the active stage and decreased IL-6 production was seen for the cells of both the active and inactive stages. Moreover, the in vitro increased production of TNFα upon stimulation with PPD-B seems to be related to persistent MAC infection, resulting in exhausted nutritional status. These results suggest that in vitro ability of both PBLs to produce IFN-γ and that of PBMs to produce TNFα and IL-6 are closely related to the clinical stage of MAC infection. 内容記述: 博士（医学）・甲第318号・平成7年3月22日 1994-10-30T15:00:00Z